Androgen esterOne of the most steroic subjects in the world of steroids is the ester--the mechanism by which injectable esterified hased like testosterone cypionate, testosterone enanthate, and Sustanon work. If you take a quick look around the Ester based steroid you will probably find countless articles that consider one form of a steroid far how to buy testosterone uk effective than another. Arguments over the superiority of cypionate to enanthate, or Sustanon to all other testosterones are of course very common. Such arguments are in all practicality, baseless. In this report we'll take an authoritative look at the ester and what specifically it ester based steroid to a steroid.
Testosterone Ester Report
One of the most misunderstood subjects in the world of steroids is the ester--the mechanism by which injectable esterified steroids like testosterone cypionate, testosterone enanthate, and Sustanon work. If you take a quick look around the Internet you will probably find countless articles that consider one form of a steroid far more effective than another. Arguments over the superiority of cypionate to enanthate, or Sustanon to all other testosterones are of course very common.
Such arguments are in all practicality, baseless. In this report we'll take an authoritative look at the ester and what specifically it does to a steroid. I'm sure that if you have taken an interest in anabolic steroids you have noticed the similarities on the labeling of many drugs.
Let's look at testosterone for example. One can find compounds like testosterone cypionate, enanthate, propionate, heptylate; caproate, phenylpropionate, isocaproate, decanoate, acetate, the list goes on and on. In all such cases the parent hormone is testosterone, which had been modified by adding an ester enanthate, propionate etc.
The following question arises: What is the difference between the various esterified versions of testosterone in regards to their use in bodybuilding? An ester is a chain composed primarily of carbon and hydrogen atoms.
This chain is typically attached to the parent steroid hormone at the 17th carbon position beta orientation , although some compounds do carry esters at position 3 for the purposes of this article it is not crucial to understand the exact position of the ester. This happens because the ester will notably lower the water solubility of the steroid, and increase its lipid fat solubility.
This will cause the drug to form a deposit in the muscle tissue, from which it will slowly enter into circulation as it is picked up in small quantities by the blood. Generally, the longer the ester chain, the lower the water solubility of the compound, and the longer it will take to for the full dosage to reach general circulation.
Slowing the release of the parent steroid is a great benefit in steroid medicine, as free testosterone or other steroid hormones previously would remain active in the body for a very short period of time typically hours. This would necessitate an unpleasant daily injection schedule if one wished to maintain a continuous elevation of testosterone the goal of testosterone replacement therapy. By adding an ester, the patient can visit the doctor as infrequently as once per month for his injection, instead of having to constantly re-administer the drug to achieve a therapeutic effect.
Esterification temporarily deactivates the steroid molecule. With a chain blocking the 17th beta position, binding to the androgen receptor is not possible it can exert no activity in the body. In order for the compound to become active the ester must therefore first be removed.
This automatically occurs once the compound has filtered into blood circulation, where esterase enzymes quickly cleave off hydrolyze the ester chain. This will restore the necessary hydroxyl OH group at the 17th beta position, enabling the drug to attach to the appropriate receptor. Now and only now will the steroid be able to have an effect on skeletal muscle tissue. You can start to see why considering testosterone cypionate much more potent than enanthate makes little sense, as your muscles are seeing only free testosterone no matter what ester was used to deploy it.
Esters vary only in their ability to reduce a steroid's water solubility. An ester like propionate for example will slow the release of a steroid for a few days, while the duration will be weeks with a decanoate ester.
Esters have no effect on the tendency for the parent steroid to convert to estrogen or DHT dihydrotestosterone: Any differences in results and side effects that may be noted by bodybuilders who have used various esterified versions of the same base steroid are just issues of timing.
Testosterone enanthate causes estrogen related problems more readily than Sustanon, simply because with enanthate testosterone levels will peak and trough much sooner week release duration as opposed to 3 or 4. Likewise testosterone suspension is the worst in regards to gyno and water bloat because blood hormone levels peak so quickly with this drug. Instead of waiting weeks for testosterone levels to rise to their highest point, here we are at most looking at a couple of days. Given an equal blood level of testosterone, there would be no difference in the rate of aromatization or DHT conversion between different esters.
There is simply no mechanism for this to be possible. There is however one way that we can say an ester does technically effect potency; it is calculated in the steroid weight. The heavier the ester chain, the greater is its percentage of the total weight. In the case of testosterone enanthate for example, mg of esterified steroid testosterone enanthate is equal to only mg of free testosterone. If we wanted to be really picky, we could consider enanthate slightly MORE potent than cypionate I know this goes against popular thinking as its ester chain contains one less carbon atom therefore taking up a slightly smaller percentage of total weight.
Propionate would of course come out on top of the three, releasing a measurable but not significant amount more testosterone per injection than cypionate or enanthate.
While the advent of esters certainly constitutes an invaluable advance in the field of anabolic steroid medicine, clearly you can see that there is no magic involved here. Esters work in a well-understood and predictable manner, and do not alter the activity of the parent steroid in any way other than to delay its release.
Although the lure surrounding various steroid products like testosterone cypionate, Sustanon, Omnadren etc. Testosterone is testosterone and anyone who is going to tell you one ester form of this or any hormone is much better than another one should do a little more research, and a lot less talking.
The "king" of testosterone blends. The four different testosterone esters in this product certainly look appealing to the consumer, there is no denying that. But for the athlete I think it is all just a matter of marketing Hell, why buy one ester when you can get four? In clinical situations I can see some strong uses for it. If you were undergoing testosterone replacement therapy for example, you would probably find Sustanon a much more comfortable option than testosterone enanthate.
You would need to visit the doctor less frequently for an injection, and blood levels should be more steadily maintained between treatments. But for the bodybuilder who is injecting 4 ampules of Sustanon per week, there is no advantage over other testosterone products. Bodybuilders should probably stop looking at the four ester issue, and stick with totals Sustanon is just a mg testosterone ampule. If you could get nearly double the milligram amount for the same price with enanthate, this is the better product to go with hands down.
Leave the high priced stuff for the guys who don't know any better. Acetate esters delay the release of a steroid for only a couple of days. Contrary to what you may have read, acetate esters do not increase the tendency for fat removal. Again, there is no known mechanism for it to do so. This ester is used on oral primobolan tablets metenolone acetate , Finaplix trenbolone acetate implant pellets, and occasionally testosterone.
Also referred to as Carboxyethane; hydroacrylic acid; Methylacetic acid; Ethylformic acid; Ethanecarboxylic acid; metacetonic acid; pseudoacetic acid; Propionic Acid. Propionate esters will slow the release of a steroid for several days. To keep blood levels from fluctuating greatly, propionate compounds are usually injected two to three times weekly.
Testosterone propionate and methandriol dipropionate two separate propionate esters attached to the parent steroid methandriol are popular items. Also referred to as Propionic Acid Phenyl Ester. Phenylpropionate will extend the release of active steroid a few days longer than propionate. To keep blood levels even, injections are given at least twice weekly. Durabolin is the drug most commonly seen with a phenylpropionate ester nandrolone phenylpropionate , although it is also used with testosterone in Sustanon and Omnadren.
Also referred to as Isocaproic Acid; isohexanoate; 4-methylvaleric acid. Isocaproate begins to near enanthate in terms of release. The duration is still shorter, with a notable hormone level being sustained for approximately one week.
This ester is used with testosterone in the blended products Sustanon and Omnadren. Also referred to as Hexanoic acid; hexanoate; n-Caproic Acid; n-Hexoic acid; butylacetic acid; pentiformic acid; pentylformic acid; n-hexylic acid; 1-pentanecarboxylic acid; hexoic acid; 1-hexanoic acid; Hexylic acid; Caproic acid.
This ester is identical to isocarpoate in terms of atom count and weight, but is laid out slightly different Isocaproate has a split configuration, difficult to explain here but easy to see on paper. Release duration would be very similar to isocaproate levels sustained for approximately one weak , perhaps coming slightly closer to enanthate due to its straight chain.
Caproate is the slowest releasing ester used in Omnadren, which is why most athletes notice more water retention with this compound. Also referred to as heptanoic acid; enanthic acid; enanthylic acid; heptylic acid; heptoic acid; Oenanthylic acid; Oenanthic acid.
Enanthate is one of the most prominent esters used in steroid manufacture most commonly seen with testosterone but is also used in other compounds like Primobolan Depot.
Enanthate will release a steady yet fluctuating as all esters are level of hormone for approximately days. Although in medicine enanthate compounds are often injected on a bi-weekly or monthly basis, athletes will inject at least weekly to help maintain a uniform blood level.
Also referred to as Cyclopentylpropionic acid, cyclopentylpropionate. Cypionate is a very popular ester here in the U. Its release duration is almost identical to enanthate days , and the two are likewise thought to be interchangeable in U. Althletes commonly hold the belief than cypionate is more powerful than enanthate, although realistically there is little difference between the two. The enanthate ester is in fact slightly smaller than cypionate, and it therefore releases a small perhaps a few milligrams amount of steroid more in comparison.
Also referred to as decanoic acid; capric acid; caprinic acid; decylic acid, Nonanecarboxylic acid. The Decanoate ester is most commonly used with the hormone nandrolone as in Deca-Durabolin and is found in virtually all corners of the world. Testosterone decanoate is also the longest acting constituent in Sustanon, greatly extending its release duration. The release time with Decanoate compounds is listed to be as long as one month, although most recently we are finding that levels seem to drop significantly after two weeks.
To keep blood levels more uniform, athletes as they have always known to do will follow a weekly injection schedule. Also referred to as Undecylenic acid; Hendecenoic acid; Undecenoic acid. This ester is very similar to decanoate, containing only one carbon atom more. Its release duration is likewise very similar approximately weeks , perhaps extending a day or so past that seen with decanoate. Undecylenate seems to be exclusive to the veterinary preparation Equipoise boldenone undecylenate , although there is no reason it would not work well in human-use preparations Equipoise certainly works fine for athletes.
Again, weekly injections are most common. Undecanoate is not a commonly found ester, and only appears to be used in the nandrolone preparation Dynabolan, and oral testosterone undecanoate Andriol. Since this ester is chemically very similar to undecylenate it is only 2 hydrogen atoms larger , it has a similar release duration approximately weeks.
Although this ester is used in the oral preparation Andriol, there is no reason to believe it carries any properties unique of other esters. Andriol in fact works very poorly at delivering testosterone, bolstering the idea that oral administration is not the idea use of esterified androgens. Also referred to as Dodecanoic acid, laurostearic acid, duodecyclic acid, 1-undecanecarboxylic acid, and dodecoic acid. Laurate is the longest releasing ester used in commercial steroid production, although longer acting esters do exist.