Estrogen Side EffectsThis is very important for the reader sidf understand, as High estrogen side effects steroids side effects can have numerous causes. The majority of the Estrogen side effects discussed here can all be treated with the use of anti-estrogens, which will be expanded upon a great deal in the next subsection Anti-Estrogens of this article. The most common and prominent estrogenic side effects will be discussed here. The most common and primary cause of gynecomastia is, of course, elevated E2 levels as a result of the extensive aromatization of hign such bigh Testosterone high estrogen side effects steroids, Dianabol Methandrostenoloneor any other anabolic steroid that is aromatizable. Secondly, Estrogen side effects can also result from compounds that are not Estrogens by nature, but tend to also bind to the Estrogen ideal female bodybuilding measurements in the body.
Estrogenic Side Effects - Gynecomastia, Bloating, Hypertension - Steroidal
This is very important for the reader to understand, as Estrogen side effects can have numerous causes. The majority of the Estrogen side effects discussed here can all be treated with the use of anti-estrogens, which will be expanded upon a great deal in the next subsection Anti-Estrogens of this article.
The most common and prominent estrogenic side effects will be discussed here. The most common and primary cause of gynecomastia is, of course, elevated E2 levels as a result of the extensive aromatization of androgens such as Testosterone , Dianabol Methandrostenolone , or any other anabolic steroid that is aromatizable. Secondly, Estrogen side effects can also result from compounds that are not Estrogens by nature, but tend to also bind to the Estrogen receptors in the body.
A perfect example of this is the anabolic steroid Anadrol Oxymetholone , which is actually unable to aromatize due to the fact that it is a DHT-derivative, and one of the key characteristics of DHT Dihydrotestosterone is that the aromatase enzyme does not recognize it as a proper substrate. Moving on to other causes of Estrogen side effects, the use of xenoestrogens can cause estrogenic effects as well, which will be touched upon later in this article xenoestrogens are non- steroidal compounds that bear no resemblance to Estrogen, yet they bind to the Estrogen receptors in the body.
Lastly, Estrogen side effects can result from rising levels of a different female ovarian steroid hormone, Progesterone or the use of Progestins, which are Progesterone-like compounds , which can act to increase the sensitivity of the Estrogen receptor to Estrogens and worsen estrogenic side effects .
The result is an environment in which even the lowest Estrogen levels can trigger estrogenic side effects. It is perhaps the most commonly discussed estrogenic side effect resultant from anabolic steroid use, and is one of the most common Estrogen side effects. Gynecomastia is also quite frequent among young pubertal males   as well as older males in the range of 45 years of age and older .
Furthermore, obese men and men with excessively high body fat percentages are common sufferers of gynecomastia, as research has found that a higher body fat percentage will present a higher risk of estrogenic side effects .
Although gynecomastia is highly concerning among males, it is far from a life-threatening Estrogen side effect, and is considered very much an aesthetically unpleasing and unattractive side effect. The water retention as a result of rising Estrogen levels can be one of the more potentially serious Estrogen side effects, but also carries with it an element of aesthetic attraction. The risk that comes with water retention is the rising blood pressure that can raise to dangerous levels, as extracellular water flows through the circulatory system causing an increase in fluid pressure against the arteries and veins .
Water is also retained subcutaneously beneath the skin also referred to as peripheral water retention and is what causes the soft, smooth, and puffy look in bodybuilders and athletes who tend to bulk up on heavy dosages of aromatizing anabolic steroids. Some might even say that the bloated, puffy look of a bodybuilder can be a telltale sign of Estrogen side effects, and therefore anabolic steroid use.
Also abbreviated as BPH, the link that Estrogen has with prostate issues in men is a fairly recent discovery, as the prevailing school of thought for a very long time was that DHT Dihydrotestosterone was the primary aggressive culprit in the issue.
First of all, there is a big difference between BPH and prostate cancer that must be clarified before moving forward. BPH is benign prostatic hyperplasia, which is the normal benign enlargement of the prostate gland, while prostate cancer is an actual carcinoma of the prostate.
It should be made perfectly clear right now to the reader that although BPH can be uncomfortable, cause urination problems, and increase the risk of urinary tract infections and subsequent inflammation , BPH does not lead to prostate cancer, and neither does it increase the risk of prostate cancer . However, research has demonstrated that the administration of Testosterone in TRT patients does not have any effect on the development of prostate cancer  , and neither are claims supported that there is an increased risk of prostate cancer in anabolic steroid users who use anabolic androgenic steroids at supraphysiological levels .
Evidence has also demonstrated that Testosterone levels in general have no direct link as a trigger to prostate cancer, though they are a necessary component . Although necessary, the growth stimulation by androgenic anabolic steroids can increase the prostate size to uncomfortable levels and can cause issues mentioned earlier, such as increased urination frequency, urination problems, inflammation, discomfort, etc.
While androgens such as Testosterone are known to play a central role, it is Estrogen that is known for playing an equally large or even larger role in prostate growth . Estrogen seems to serve the role of increasing the number and proliferation of androgen receptors in the prostate gland, and therefore the increases in the number of androgen receptors results in a significant increase in growth rate even among a reduction in androgen levels .
Much like how gynecomastia is significantly influenced by the androgen: Now, going back to prostate cancer quickly, there is very strong evidence demonstrating that Estrogen is indeed a strong cancer-causing agent where the prostate is concerned, where elevated levels of Estrogen are associated with prostate cancer.
The evidence demonstrates changes in Estrogen receptor status in advanced prostate cancer as well as rodent models and chimeric human tissue graft models demonstrating induction of prostate cancer using Estrogen as well as Testosterone .
Furthermore a variety of different of Estrogen receptors have been discovered on the prostate gland, and Estrogen does not only exacerbate BPH as mentioned earlier , but it also exacerbates malignant prostate cancer via receptor-mediated mechanisms, DNA-damaging, as well as potentially mutagenic activity of Estrogens and estrogenic compounds .
There is evidence that in addition to the negative estrogenic side effects as it relates to the prostate, it also seems to exhibit some beneficial protective effects as well . On the positive side, the stimulation of Estrogen receptor-beta can assist in the protection of the prostate from inflammation, hyperplasia, and some carcinogenesis.
It is the Estrogen receptor-alpha that is responsible for negative effects mentioned earlier. It is safe to conclude, however, that a very high level of Estrogen seems more harmful for the prostate than beneficial as elevated levels of PSA have been recorded during anabolic steroid administration both mild and heavily estrogenic anabolic steroids were used . Kasper , Stephen L. Larry Jameson, and Kurt J. Mayo Clinic Proceedings 84 Nippon Naibunpi Gakkai Zasshi 62 Rossler R, Internist Berl.
Effect of ovarian steroids on vasopressin secretion. Sex hormone effects on body fluid regulation. Exerc Sports Sci Rev. Is there a link between BPH and prostate cancer? Testosterone therapy in hypogonadal men and potential prostate cancer risk: Long-term psychiatric and medical consequences of anabolic-androgenic steroid abuse: A looming public health concern?
Epub Jul 2. Epub Jun Estrogen action and prostate cancer. Expert Rev Endocrinol Metab. The Role of Estrogens in Prostate Carcinogenesis: A Rationale for Chemoprevention. Estrogen action on the prostate gland: J Mol Endocrinol 39, Scand J Urol Nephrol. Effects of androgen therapy on prostatic markers in hemodialyzed patients. Dan's educational emphasis is on performance enhancement drugs PEDs , endocrinology, nutritional supplements and strategies for health, fat reduction, anti-ageing, muscle growth, disease control and vaccinations.
Dan has had an interest in learning and writing about steroid use for over 15 years. Gynecomatia from steroidal estrogenic side effects.