Post cycle therapy (PCT)After a cycle, we have one goal: Unfortunately, this is easier said than done, because the levels of various hormones and other substances that were circulating around your body during the cycle huge amounts of testosterone, insulin-like growth factor, growth hormone, and lower amounts of muscle-wasting glucocorticoids are now changing. Sadly, post cycle for anadrol are stacking winny and anavar way for lower amounts of the hormones we want for building muscle, and higher amounts of the catabolic ones. What needs to be done, as post cycle for anadrol as possible, corticosteroids pharmacology to get your body to begin production of your own natural anabolic hormones, and produce less of the catabolic ones. Unfortunately, your body has other plans.
Best post cycle therapy following anadrol cycle | The Iron Den
After a cycle, we have one goal: Unfortunately, this is easier said than done, because the levels of various hormones and other substances that were circulating around your body during the cycle huge amounts of testosterone, insulin-like growth factor, growth hormone, and lower amounts of muscle-wasting glucocorticoids are now changing. Sadly, they are making way for lower amounts of the hormones we want for building muscle, and higher amounts of the catabolic ones. What needs to be done, as quickly as possible, is to get your body to begin production of your own natural anabolic hormones, and produce less of the catabolic ones.
Unfortunately, your body has other plans. Is all of this necessary? No, not at all. You can skip to the end of the article and look for a little chart I made - the extent of my computer skill - which has all of the dosage recommendations and compounds involved to properly recover from your cycle. FSH, although generally thought to only have a role in production of sperm, actually aids the in regulation of Leydig Cell function 2 , while LH directly causes the Leydig Cells in the testes to secrete androgenic hormones such as testosterone which is causes a surge in other anabolic hormones: What does this mean?
In the case of testosterone, for example, one of the messages it sends to the cell is to increase nitrogen retention in your body, thus allowing you to use more of the protein you take in, and build more muscle.
In the case of testosterone or anabolic steroids in general , this transcription causes a lot of different anabolic effects to take place: This is not to say that AR binding is the only thing that causes anabolic or androgenic effects, however.
Oxymetholone and Methandrostenolone Anadrol and Dianabol both bind very weakly to the AR yet are both highly anabolic and androgenic.
Under the control of this heightened state of androgens, you also go through androgenic development as well as anabolic development. This can be seen in puberty when males grow body hair experience voice changes, as experience genital development and growth.
Lets review one of the first things I mentioned, ok? Ok, now, once testosterone is created however, it has the ability to in turn to undergo various metabolic processes that will inhibit GnRH, which in turn inhibits the secretion of LH and FSH, and that brings a halt to natural testosterone production. Once testosterone has stopped being produced, it no longer sends this negative signal, and GnRH eventually begins to do its job again.
In this way, your body prevents excess hormones from being secreted and thus maintaining homeostasis the status quo… in this case a state where you are neither gaining nor losing muscle 1. This negative feedback loop is partially why we use anabolic steroids…we want more testosterone for anabolic purposes or more Anavar or whatever than our body will let us produce not that our bodies produce Anavar, but you get the idea.
The chart below clearly shows this process, displaying both the negative and positive feedback system s:. Am I being repetitive? Remember, the negative feedback loop is, of course, no problem while we are on a cycle. Want more testosterone or androgens in your body? Fill up a few more syringes! But all good things come to an end, and most of us choose to end our cycles at some point. SO what we need to do is coax the body into quickly producing its own androgens.
Nolvadex Tamoxifen is a SERM Selective Estrogen Receptor Modulator, which means that it has the ability to act as an anti-estrogen with regard to certain genes, yet also acting as an estrogen with respect to others. It does this by blocking gene transcription in some cases, and initiating gene transcription in others 3. Luckily for us, it has estrogenic effects on bones meaning it increases their density , and blood lipids -meaning it lowers cholesterol-, 4 5 as well as preventing gynocomastia by preventing estrogen gene transcription in breast tissue.
However, it acts as an anti-estrogen in the pituitary, thus increasing LH and FSH, which results in an increase in testosterone. Nolvadex actually has quite a few applications for the steroid using athlete. Nolvadex does this by actually competing for the receptor site in breast tissue, and binding to it.
Thus, we can safely say that the effect of tamoxifen is through estrogen receptor blockade of breast tissue 7. Estrogen is also important for a properly functioning immune system, and not only that, but your lipid profile both HDL and LDL should also show marked improvement with administration of tamoxifen Nolvadex also has some important features for the steroid using athlete.
In hypogonadic and infertile men given nolvadex, increases in the serum levels of LH, FSH, and most importantly, testosterone were all observed 35 It can also block a bit of estrogen in the pituitary, which is a great benefit when used with HCG more on that later 36 Well, basically because it takes much more to do the same thing.
In comparison, it would require mgs of Clomid to accomplish that type of elevation in testosterone, but Nolvadex also has the added benefit of significantly increasing the LH Leutenizing Hormone response to LHRH LH-releasing hormone 6. This most likely indicates some kind of upregulation of the LH-receptors due to the anti-estrogenic effect Nolvadex has at the pituitary.
As you already know, Nolvadex is highly anti-estrogenic at the hypothalamus and pituitary, while Clomid exhibits weak estrogenic activity at the pituitary 7 , which as you can guess, is less than ideal.
Need I even add that the mgs of Clomid you need to get the hormonal increase experienced with 20mgs of Nolvadex is much more expensive? I favor using 20mgs. So that effectively suggests Nolvadex can not be used at Mega-doses to get a mega-increase in your natural hormones. Arimidex an Aromatase Inhibitor —which means it stops the conversion of testosterone into estrogen-another drug used to fight breast cancer like Nolvadex exhibits basically the same effects when.
It must be, therefore, that your body can only respond with so much vigor to any one drug in those families. So lets add in another drug or two, ok? This way we can use reasonable doses of a few drugs and produce some synergy…hopefully decreasing our recovery time. HCG is the natural choice, as it has been used successfully to cure AAS induced 11 , and this alone warrants its inclusion to our cycle. Obviously, as you can guess from the name, it is a substance that stimulates the gonads hence: It does this by initiating gene transcription that is identical to that of Luetenizing Hormone, thereby causing the Leydig Cells to produce testosterone.
We can stimulate LH and FSH production with our Nolvadex, and then directly stimulate the Leydig Cells as well, to produce tons of testosterone by different routes! Unfortunately, while HCG increases Testosterone, it increases estrogen as well As you probably know, estrogen acts directly on the Leydig cells to effect changes in the activities of enzymes important for testosterone synthesis 13 and may actually be considered an important part of that negative feedback loop I mentioned earlier.
In addition, an increase in circulating levels of LH have been shown to induce down-regulation of LH-receptors in both rodent studies 14 , as well as in human studies 15 ; since HCG mimics LH, you can expect it to do the same. This LH downregulation can cause an increase in steroidogenic cholesterol the cholesterol earmarked by your body for conversion into testosterone.
Thus, after the initial HCG induced surge in testosterone is over, if you have used enough to downregulate your LH-receptors and increase estrogen too much, then more steroidogenic cholesterol is available.
This is telling me that less is being converted to testosterone. In fact, rodent models suggest that if you take a dose large enough to cause a sharp increase of plasma testosterone, you will actually desensitize your Leydig cells to your next shot, and will possibly not experience any rise in testosterone from the second dose at all, or may only experience a very slight one at best Low LH post-cycle is not the primary cause of slow recovery, because LH generally rises to levels above baseline after a cycle much sooner than testosterone production does.
This is probably because the pituitary is working very hard to get your atrophied Leydig cells to start producing testosterone again. This suggests that a pre-exposure to normal LH levels or gonadatropins in general is necessary for HCG-induced Leydig Cell desensitization.
But are we still risking some inhibition and possibly delaying our recovery by using HCG? Probably not…you see, some studies in humans have shown that HCG does not actually have a direct effect on inhibiting LH release in men 22 23 , but rather probably works to inhibit LH secretion indirectly, simply by stimulating the production of testosterone thus activating the negative feedback loop.
Another factor involved is the induction of testicular aromatase, which raises estrogen levels, again causing inhibition. Unfortunately, yet another process, the downregulation of the Leydig Cell LH receptor itself, seems to also play a role in high dose HCG testicular desensitization.
Nolvadex actually stops this blocking-action of HCG from taking place Well…we can use low doses iu or so to avoid some of that major spike in estrogen, and thus cause far less inhibition from the HCG Maybe we can get away with taking some Vitamin E with our HCG, since it increases the responsiveness of plasma testosterone levels to HCG, making them significantly higher during vitamin E administration than without it Lets add in an Aromatase Inhibitor!
Aromasin can also cause androgenic sides 29 30 31 , which may help to elevate your mood while you are on PCT. With this PCT, there will be a rapid increase in LH, FSH, and testosterone, as well as almost a complete block on all the factors that could be causing your natural hormones to be delayed in returning to baseline.
For this reason, I feel that the second your cycle is over is when you should start this PCT a week after your last shot, or the day after your last pill is fine. And how long do we run this for? Well…we need to stop the HCG relatively soon for reasons discussed earlier. But the Nolvadex, and Aromasin can be used for awhile longer. And with no further delays, here are my recommendations for PCT:. Anthony Roberts has been researching anabolic steroids for over a decade and is the author of the book, Anabolic Steroids: He began his research at the age of seventeen while he was a competitive martial artist, ultimately winning a silver medal in his state martial arts tournament in the black belt division.
His firsthand experience in steroids began after he switched sports and began playing rugby, in which he ultimately made two consecutive appearances at the hooker position in the national collegiate all-star games.
Remember, during this lag-time you lose gains, so we really need to make it as short as possible. First, we need to understand a bit of what is going on in your body, what causes it to happen naturally, and what hormones are performing what function. The chart below clearly shows this process, displaying both the negative and positive feedback system s: Lets solve that pesky estrogen problem now….
And with no further delays, here are my recommendations for PCT: