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Citation Count is the number of times that this paper has been cited by other published papers in the database. The Altmetric Attention Score is a weighted count of all of the online attention Altmetric have found for an individual research output. This includes mentions in public policy documents and references in Wikipedia, the mainstream news, social networks, blogs and more. More detail on the weightings of each source and how they contribute to the attention score is available here.
The Relative Citation Ratio RCR indicates the relative citation performance of an article when comparing its citation rate to that of other articles in its area of research. A value of more than 1. The RCR is normalized to 1. The Field Citation Ratio FCR is an article-level metric that indicates the relative citation performance of an article, when compared to similarly-aged articles in its subject area. The FCR is calculated for articles published in and later. The recent citations value is the number of citations that were received in the last two years.
It is currently reset at the beginning of each calendar year. Patent citations is the number of times that this record has been cited by other published patents. Patents may be registered in several offices, and this may effect patent citation data. Publication - Article Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. The synthesis of dihydrotestosterone is catalyzed by steroid 5 alpha-reductase isozymes, designated types 1 and 2.
Mutation of type 2 results in male pseudohermaphroditism, in which the external genitalia are phenotypically female at birth. Two striking and unexplained features of this disorder are that external genitalia of affected males undergo virilization during puberty and that these individuals have less temporal hair regression. The tissue-specific and developmental expression patterns of the 5 alpha-reductase isozymes were investigated by immunoblotting.
The type 1 isozyme is not detectable in the fetus, is transiently expressed in newborn skin and scalp, and permanently expressed in skin from the time of puberty. There was no qualitative difference in 5 alpha-reductase type 1 expression between adult balding vs. The type 2 isozyme is transiently expressed in skin and scalp of newborns. Type 2 is the predominant isozyme detectable in fetal genital skin, male accessory sex glands, and in the prostate, including benign prostatic hyperplasia and prostate adenocarcinoma tissues.
Both isozymes are expressed in the liver, but only after birth. These results are consistent with 5 alpha-reductase type 1 being responsible for virilization in type 2-deficient subjects during puberty, and suggest that the type 2 isozyme may be an initiating factor in development of male pattern baldness.
Publication citations Citation Count is the number of times that this paper has been cited by other published papers in the database.