OxandroloneClose menu Log in Register. Dbol, Anadrol, Winstrol, Anavar, Etc Oral Steroids and Liver Toxicity: Liver Toxicity and Oral Steroids: Are the Risks Over-exaggerated?
Oral Steroids and Liver Toxicity: Dbol, Anadrol, Winstrol, Anavar, Etc
Close menu Log in Register. Dbol, Anadrol, Winstrol, Anavar, Etc Oral Steroids and Liver Toxicity: Liver Toxicity and Oral Steroids: Are the Risks Over-exaggerated? Certainly, this new idea is in bold contrast to the decades of steroid research which has been conducted in human beings at numerous universities.
The point of this article is not meant to minimize the potentially serious side effects associated with irresponsible oral AAS use, but to inform the reader of the truth regarding this class of drugs and their risks to the liver. Without wasting time, I will get right to the point and say that the toxicity of oral AAS and their overall risks to the liver, in general, have been greatly exaggerated over the last several years, leading many to adopt a position which is both unnecessary and ignorant.
To be blunt, in the average healthy person with no pre-existing liver conditions, it would take a small mountain of oral AAS consumed over a considerable period of time, in order to experience irreparable liver damage. Otherwise, we would see significantly more people requiring a liver transplant, but let me ask you a question. You see, the liver is a very resilient organ, which is not only capable of sustaining a tremendous workload, but is actually able to repair itself in the event it does sustain damage.
In order for the liver to fail to the point of replacement, it must be provided with an extreme workload, to the point that its filtering capacity is consistently overwhelmed, leading to severe damage and an inability to regenerate. These conditions require treatment for longer than 4 weeks if they are to be effective. I am convinced that the reason for the recent change in mind-set regarding optimal cycle length with oral steroids has been largely due to the cycling recommendations of OTC designer steroid companies.
There were two reasons why we witnessed OTC companies advising such short cycle guidelines, both of which are understandable. By keeping their cycle recommendations well within safety limits, they minimized the possibility of a potential lawsuit. While there are no doubt some oral AAS which are best left for short-term use 4 weeks or less , the large majority can safely be used for between weeks at standard dosages.
Some of the oral AAS included in this group include: While I am not going to list appropriate cycle guidelines for each oral steroid in existence, this should provide the reader with an idea of just how many steroids can be responsibly used in the week range.
For those of you who are more conservative or desire to take precautions against the hepatotoxic effects of oral AAS, there are several preventative measures, which can be taken to significantly reduce the strain placed on the liver. These include the implementation of various OTC supplements, as well as temporary abstinence from all other unnecessary liver toxic drug, such as alcohol, Tylenol, and various prescription medications.
Most are relatively inexpensive and make a worthy addition to any oral steroid cycle, especially when AAS are used regularly. In the next section of this article, I have re-printed some studies and abstracts from Pub-Med, which demonstrate a more accurate view of oral AAS and their potential to cause liver injury.
In the study below, the aim was to determine whether or not Anadrol positively affects insulin sensitivity the answer appears to be yes. Oxymetholone ameliorates insulin sensitivity in maintenance hemodialysis patients: To investigate the beneficial effects of oral oxymetholone on IR in hemodialysis HD patients by increasing skeletal muscle function and stimulating myocyte glucose uptake and metabolism. In a randomized, controlled double-blind study, 44 patients were randomly assigned to one of two groups: All patients were encouraged to walk at least one kilometer daily and were monitored by the Barthel index activity score.
The mean age of patients and the duration of dialysis were After treatment, the HOMA index and body fat mass FM were significantly decreased in the treatment group compared to those in the control group HD patients treated with short-term oral oxymetholone showed an increase in insulin sensitivity when compared to the placebo group, and this effect depended on changes in FFM and FM.
When these test subjects were administered a full mg daily dose of Anadrol for 24 weeks straight 6 months , only 2 out of the 21 subjects treated experienced notably elevated liver enzymes Oxymetholone for the treatment of HIV-wasting: Despite highly active antiretroviral therapy HAART , chronic involuntary weight loss still remains a serious problem in the care of HIV patients due to various alterations in energy metabolism and endocrine regulation.
Previous studies in HIV-positive men undergoing androgen replacement therapy or treatment with recombinant growth hormone rGH have shown partial restoration of lean body mass LBM , but these treatments have largely not been sufficiently studied in eugonadal individuals. A double-blind, randomized, placebo-controlled trial of 89 HIV-positive eugonadal women and men with wasting assigned to the anabolic steroid oxymetholone bid or tid or placebo for 16 weeks was performed. Body weight, bioimpedance measurements, quality of life parameters, and appetite were analyzed.
Oxymetholone led to a significant weight gain of 3. Oxymetholone can be considered an effective anabolic steroid in eugonadal male and female patients with AIDS-associated wasting.
Oxymetholone promotes weight gain in patients with advanced human immunodeficiency virus HIV-1 infection. Department of Dermatology, University of Essen, Germany.
Clinical Trial; Randomized Controlled Trial The effect of the testosterone derivative oxymetholone alone or in combination with the H1-receptor antagonist ketotifen, which has recently been shown to block tumour necrosis factor alpha TNF alpha , on weight gain and performance status in human immunodeficiency virus HIV patients with chronic cachexia was evaluated in a week prospective pilot study.
Thirty patients were randomly assigned to either oxymetholone monotherapy n 14 or oxymetholone plus ketotifen n Patients receiving treatment were compared with a group of thirty untreated matched controls, who met the same inclusion criteria. Body weight and the Karnofsky index, which assesses the ability to perform activities of daily life, and several quality-of-life variables were measured to evaluate response to therapy.
The average weight gain at peak was 8. Hepatic effects of 17 alpha-alkylated anaboli-androgenic steroids. Use of 17 alpha-alkylated anabolic-androgenic steroids 17alpha-AAS has been connected to hepatotoxicity.
These steroids are used clinically to treat anemia, to prevent weight loss, and to treat wasting syndrome. Liver disease and the effects of some anti-HIV drugs may contribute to hepatic dysfunction. Signs of hepatic dysfunction are listed. For those experiencing jaundice and related malfunctions, discontinuing the drug enables patients to recover.
In many cases those who did not exhibit jaundice may have developed a tolerance for the drugs. Side effects such as cholestatic jaundice only occurred in a small number of patients taking the recommended doses of 17alpha-AAS. Peliosis hepatitis, hepatic tumors, and hepatocellular adenomas are other reported side effects.
Proper dosing and monitoring of anabolic steroids reduces the risk of hepatotoxicity. In a review of the literature above, the author clearly states that side effects such as jaundice have only occurred in a small amount of patients being treated with Anadrol.
The author then goes on to state that those experiencing jaundice and other liver-related side effects recover upon discontinuance of the drug, with proper dosing and monitoring further reducing the risk of hepatotoxicity.
As you can see from the references above, even the most toxic prescription oral steroid, Anadrol, has been deemed safe for use when dosed responsibly and when combined with proper monitoring.
The above studies ranged from weeks in length using doses of mg per day, yet only the minority experienced an elevation in liver enzymes which was concerning to the medical researchers. If Anadrol can safely be used for extended periods of time under appropriate circumstances, then it seem reasonable to ascertain that less toxic steroids, such as Dianabol, can still be used for traditionally accepted week cycles. HackTwat liked this post. Not a bad idea brother.
I can run all the liver blood tests if anyone wants to do it Floating this to the top since we have a poll on least toxic orals in winny, dbol, and drol,. Web Hosting Web Hosting. Runs best on HiVelocity Hosting. We do not condone nor promote the use of any illegal substances that may or may not be mentioned by our members. We are an international bodybuilding forum and host members from around the globe.
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