Influence of androgens and anabolic steroids on adrenal and thyroid function - ScienceDirect
Because use of anabolic steroids is illicit, much of our knowledge of their side effects is derived from case reports, retrospective studies, or comparisons with studies in other similar patient groups. It has been shown that high-dose anabolic steroids have an effect on lowering high-density lipoprotein, increasing low-density lipoprotein, and increasing the atherogenic-promoting apolipoprotein A. Steroid abuse can also be hepatotoxic, promoting disturbances such as biliary stasis, peliosis hepatis, and even hepatomas, which are all usually reversible upon discontinuation.
Suppression of the hypothalamic adrenal axis can also lead to profound adrenal changes that are also reversible with time. Much of our knowledge of these potentially severe but usually limited side effects is confounded by use of combinations of different steroid preparations and by the concomitant use with other substances.
Physicians must target their efforts at counseling adolescents and other athletes about the potential harms of androgenic anabolic steroids and the legal options to improve strength and performance.
Unable to display preview. The effect of anabolic steroids on the gastrointestinal system, kidneys, and adrenal glands. This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access. In Sport and Exercise Pharmacology. Recent good review of the pharmacology of anabolic steroids and their biochemical properties. Looks at how chemical substances affect exercise performance in athletes.
Adverse effects of anabolic steroids. Med Toxicol Adverse Drug Exp , 4: Abuse of supraphysiologic doses of anabolic steroids.
South Med J , Most recent review article regarding specific side effects of high doses of AAS. The article then reviews the major side effects broken down by organ system. A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids. Clin Ther , National Institutes of Health Publication No. National Institutes of Health; Clin Sports Med , A comprehensive review of four different types of anabolic agents used by athletes.
The article reviews physiology and chemistry as well as performance and medical side effects. Am J Sports Med , Endocrine aspects of anabolic steroids. Clin Chem , Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein a.
Br J Sports Med , A recent study evaluating the effects of anabolic agents on apolipoproteins and overall lipid panel in strength athletes. The study is nonblinded, but looks at the relationship between changes in lipids profiles as they may be further indicators of cardiovascular risk. Focuses predominantly on HDL subfractions and apolipoprotein a and lipoprotein.
Hartgens F, Kuipers H: Effects of androgenic-anabolic steroids in athletes. Sports Med , Effects of nandrolone decanoate on serum Lp a , lipids, and lipoproteins in women with postmenopausal osteoporosis. Scand J Clin Lab Invest , Nandrolone decanoate reduces serum lipoprotein a concentrations in hemodialysis patients. Am J Kidney Dis , Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives.
J Allergy Clin Immunol , Hepatic toxicity of androgen therapy in aplastic anemia. Nouv Rev Fr Hematol , Hypercholesteremia in male power lifters using anabolic-androgenic steroids. Physician Sportsmed , Peliosis hepatis associated with androgenic-anabolic steroid therapy-a severe form of hepatic injury. Ann Intern Med , Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: A case report of two male body builders using high doses of AAS who developed serious liver disease, including adenocarcinomas.
One patient was asymptomatic; the other was hospitalized for acute renal failure as well. The cases follow the patients and shows the long-term reversibility of the disease and the need for monitoring of patients taking AAS. Pathology of hepatocellular carcinoma. Effects of anabolic steroids on physical health. In Anabolic Steroids in Sport and Exercise. Endocrine consequences of androgenic-anabolic steroids in male athletes. Popular sports supplements and ergogenic aids.