METAPRIME (methandienone oral)While such side androgdnic are rare, most of them are associatedwith the fact that DHEA is a precursor for the primary sexhormones in the body, estrogen and testosterone. While DHEA has consistently provided fat-loss benefits in animal anabolic androgenic research oblivion, the studies with humans are far less conclusive. However, a follow-up study later released, using the same dose of DHEA, failed to show any fat loss at all in another group of men. Older people provided with DHEA in far smaller doses--averaging milligrams daily--show anabolic androgenic research oblivion effects in lean mass attributed to DHEA promotion of IGF-1 secretionbut virtually no changes in bodyfat levels. Those studies with older people also showed that while diana palmer wyoming bold en espanol effects of DHEA were beneficial, the fact that DHEA readily converted into other hormones led to some possible problems.
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While such side effects are rare, most of them are associatedwith the fact that DHEA is a precursor for the primary sexhormones in the body, estrogen and testosterone. While DHEA has consistently provided fat-loss benefits in animal studies, the studies with humans are far less conclusive.
However, a follow-up study later released, using the same dose of DHEA, failed to show any fat loss at all in another group of men. Older people provided with DHEA in far smaller doses--averaging milligrams daily--show beneficial effects in lean mass attributed to DHEA promotion of IGF-1 secretion , but virtually no changes in bodyfat levels. Those studies with older people also showed that while the effects of DHEA were beneficial, the fact that DHEA readily converted into other hormones led to some possible problems.
In women, DHEA usually converts into testosterone. Some older women showed increases in basal testosterone levels 9-fold over normal. While many bodybuilders would rejoice over a comparable testosterone increase, in the older women this level of testosterone often led to a drop in protective high density lipoprotein cholesterol levels HDL. When HDL levels decline as they always do when using oral anabolic steroids , the risk of cardiovascular disease onset increases.
In older and younger men, the fate of DHEA varied depending of the existing hormonal milieu of the individual. Most often, the DHEA converted into androstenedione, which is commercially available as a so-called "pro-hormone.
These conversions can lead to such side effects as male pattern baldness if genetically predisposed , acne, or gynecomastia male breasts. The main benefit of 7-keto DHEA is that, because of its structure, it isn't prone to conversion to either testosterone or estrogen, thus eliminating any side effects associated with those hormonal conversions.
The toxicology and endocrine effects of 7-keto DHEA were examined in studies presented at the Experimental Biology 98 meeting. In one study, the safety of 7-keto was examined in rats and monkeys. In the rat study, 5 groups of rats were given 0, , , 1,, or 2, milligrams per kilogram of 7-keto in a single dose. After 15 days, the animals were killed and then examined. The results showed that even a 2, milligram dose of 7-keto didn't produce any observable side effects in the rodents.
The researchers then examined the effects of 7-keto DHEA on rhesus monkeys, a species closer to humans than rats at least, closer in some people. On days , the monkeys got 1, milligrams per kilogram of 7-keto. On the 12th day, the monkeys were killed. Once again, autopsy of the monkeys showed "no adverse clinical or anatomical pathology results. While these animal studies do appear to show a high safety factor associated with 7-keto DHEA, it still doesn't completely apply to human usage.
So another study presented at the same scientific conference looked at the hormonal and safety effects of 7-keto DHEA in human subjects. The study consisted of men between the ages of 18 and 49, 18 of whom took 7-keto DHEA, while another 6 took a placebo or inactive substance for 8 weeks.
The dose of 7-keto were gradually increased to milligrams, twice daily during the final 4 weeks of the study. The levels of hormones in the men before using 7-keto or the placebo didn't differ either before or during treatment.
However, at the end of the study, the men taking genuine 7-keto DHEA showed a small reduction in total testosterone levels in addition to a clinically insignificant increase in free or active testosterone levels. Since no significant changes occurred in any hormone levels in those taking the real 7-keto DHEA, the study authors concluded that,"This study shows that 7-keto DHEA is well-tolerated at doses up to milligrams a day, and does not produce clinically important sex hormone changes in healthy men.
The rats were given a drug called scopolamine that interferes with the activity of acetylcholine, a vital brain neurotransmitter required for memory processes. In rats given 7-keto DHEA at a dose of just 20 milligrams per kilogram of bodyweight, the memory-interference effects of scopolamine were nullified. Control rats not taking either DHEA or 7-keto found the pedestal in 34 seconds. Those taking DHEA found the pedestal in 22 seconds. In the 7-keto group, the rats located the pedestal in 7.
This indicates that 7-keto shows memory-enhancing effects that are clearly superior to that of regular DHEA. Do soy isoflavones affect testosterone in men? Soy isoflavones, such as genistein and others, have been touted as having many important preventive health effects. These include cardiovascular disease prevention through antioxidant effects, and cancer prevention by interfering with the activity of hormones such as estrogen that are associated with several types of cancer in women.
These same isoflavones are linked to a lower prevalence of prostate cancer in men. But since these isoflavones have a chemical structure similar to estrogen, and since high levels of estrogen may interfere with testosterone activity in men, the question is: This question is examined in two studies published in the American Journal of Clinical Nutrition ;68 suppl: In the first study, the effects of phytoestrogens or plant estrogens such as the isoflavones were investigated in 13 older women and 12 middle-aged men.
The subjects were given 40 grams a day of linseed oil containing a natural precursor to lignan, a fiber known to have effects on hormones in the body, and 60 grams a day of textured soy protein containing 45 milligrams of isoflavones. The study subjects took the linseed for weeks and the soy protein for 4 weeks, both incorporated into bread rolls. The results showed that serum gonadotropin levels FSH and LH were suppressed by both the linseed and soy protein.
While consuming the linseed, the serum androgen levels dropped in 6 of the male subjects, although there was no changes in urinary androgen levels. Both total and low density lipoprotein cholesterol decreased with the linseed intake, with a significant drop showing up in the female subjects.
Note that serum androgen levels i. Lignan, found in the linseed, is a form of fiber, and this accounts for the beneficial effects shown in lowering plasma lipids, such as total cholesterol and LDL cholesterol.
This would have a preventive effect on cardiovascular disease onset. Linseed also locks on to sex hormones in the body, promoting the excretion of such hormones. This effect may have been more potent with estrogens in this study, since the male subjects showed lower serum androgen levels, but no greater excretion of androgens through the urine. The drop in serum androgens in the men was probably the result of both the linseed and soy slightly interfering with gonadotropin release LH.
This may be due to the estrogen-like structure of isoflavones, since estrogen is known to be a potent inhibitor of gonadotropin release. In fact, this is the main mechanism behind oral contraceptives, which contain synthetic estrogens. The decrease in gonadatropins shown in the study is problematic, even though the men didn't appear to be adversely affected as judged by the lack of change in androgen excretion.
Another study looked closer at this issue of how soy intake affects hormone levels in the body. Unlike the previous study, this study was more specific since it only focused on soy products.
Again, the study involved older women and younger men, who ingested 12 ounces a day of soy milk with each meal for one month. The isoflavone intake each day averaged milligrams of genistein and milligrams of daidzein, considered the most active and biologically important isoflavones found in soy.
The men showed no changes in serum testosterone levels. This is a beneficial effect, since DHT, a metabolite of testosterone, is considered to be responsible for promoting male pattern baldness, acne, and prostate enlargement.
Thus, soy may provide a DHT reduction effect without adversely affecting normal testosterone synthesis or release. In another study, this time involving rats, Chinese researchers focused on the effects of the soy isoflavone, daidzein on muscle growth and hormone levels in the rodents. The daidzein was given to both male and female rats in a dose of 3 milligrams per each grams of bodyweight.
The daidzein was injected subcutaneously into the animals for 16 days. Compared to a control group not getting the daidzein, male rats showed a bodyweight gain of The rats on daidzein also showed lower nitrogen excretion an indication of greater protein retention in the body , and increased levels of testosterone, estrogen, beta-endorphin, and growth hormone. The study authors concluded that the muscle growth effects of daidzein appear to be linked to normal testosterone production.
Want to know the truth about them? The Applied Ergogenics blog is a collection of articles written and published by Jerry Brainum over the past 20 years. These articles have appeared in Muscle and Fitness, Ironman, and other magazines. Many of the posts on the blog are original articles, having appeared here for the first time.
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